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Not merely its volume and also the practical Homes of Hb affect overall performance. This is illustrated through the observation that an elevated Hb-O2 affinity favors O2 loading while in the lung and survival within an hypoxic setting (Eaton et al., 1974; Hebbel et al., 1978), While a diminished Hb-O2 affinity favors the release of O2 from the Hb